Salmon DNA Injection (PN/PDRN) in Myeongdong & Jongno, Seoul

What is a salmon DNA injection?

In Korean clinics you will hear many names for the same family of treatments: salmon injection, DNA injection, yeoneo juseo, PN or PDRN booster. All of them refer to purified fragments of DNA, extracted from salmon or trout, which are injected into the dermis. The DNA is highly purified so that it is compatible with human tissue; it does not contain fish proteins in meaningful amounts, but because of its origin, a fish allergy is still a reason not to treat.

Two forms are used. Polynucleotides (PN) are longer DNA chains with higher molecular weight; they form a viscous gel that is thought to act as a temporary scaffold in the dermis while also hydrating it. PDRN (polydeoxyribonucleotide) consists of shorter fragments and has a longer history in wound-healing research. A 2024 review in the International Journal of Molecular Sciences summarises these differences and notes that PDRN is thought to act partly through adenosine A2A receptors, which are involved in tissue repair and new blood vessel formation.

Rejuran is the best-known PN brand and has its own dedicated page. Here we explain the wider PN and PDRN category, so you understand what you are being offered whichever brand name appears on a menu.

PN vs PDRN: what is the difference?

The short answer: PN is usually chosen for structural repair and elasticity, PDRN for calming and healing. In practice, both support a healthier dermal environment, and the choice depends on your skin and on what is combined with it.

PN products are more viscous and are injected as small deposits, often leaving temporary bumps. PDRN products are thinner and are often delivered with microneedling or injector devices, and are sometimes used right after laser to help recovery. Neither is a filler. If your main problem is volume loss or sagging, they will not correct it on their own; collagen stimulators such as Juvelook, lifting devices or fillers do that job.

What does the research say?

We want you to understand both the promise and the limits. A 2026 systematic review and meta-analysis of randomised trials found that polynucleotides improved scar texture, elasticity and hydration compared with placebo, performed similarly to hyaluronic acid overall and better on some objective texture measures, with only mild, temporary side effects. However, that analysis included just five trials and 315 patients.

The 2024 review of current practice reached a similar view: many studies report benefit and good safety, but large, high-quality, long-term trials are still scarce and the exact mechanism of PN in human skin has not been fully proven. That is why we describe salmon DNA boosters as a well-tolerated, reasonable option for skin quality, not as a miracle or a substitute for sun protection and good skincare.

How we decide if PN or PDRN suits your skin

Obliv's Skin Architecture method looks at each layer. Salmon DNA boosters target the dermis, so they suit concerns rooted there: thin skin, loss of resilience, fine lines and slow recovery. Surface pigment needs laser; deeper sagging needs lifting; muscle-driven lines need Botox.

Your consultation starts with Mark-Vu skin analysis to look at redness, texture and pores, then a hands-on assessment of skin thickness. The product, dose and technique are recorded in your Skin Library, so you can continue a comparable course at home.

Who is a good candidate?

Salmon DNA boosters suit adults whose skin looks tired, thin or reactive, people who have had a lot of laser or active skincare and need recovery, and those with fine lines or shallow scars. They are often a good first booster for sensitive skin, and pair well with gentle pigment or redness lasers. Our page on redness and sensitive skin describes how we combine them.

We do not treat if you have a fish or salmon allergy, are pregnant or breastfeeding, or have an active infection in the area. If you have an autoimmune condition or a history of unusual reactions to injections, we discuss the decision carefully first.

Your appointment step by step

PN and PDRN combine well with laser, which is usually performed first. For an example, read microneedling plus skin booster in Korea.

1. Before you travel: send daylight photos without make-up and your dates by WhatsApp; mention allergies.
2. Consultation and Mark-Vu imaging: the doctor explains PN vs PDRN for your skin and gives a written plan.
3. Numbing: cream for about 30 minutes.
4. Treatment: 15–30 minutes by needle, injector device or microneedling.
5. Soothing and aftercare: calming care and written instructions.

Results timeline

Salmon DNA boosters work gradually. The first change many patients notice is that their skin feels more comfortable and less reactive; smoother texture and softer fine lines follow over several weeks and across sessions.

After a full course of two to four sessions, results often last around six to twelve months for PN, and somewhat less for lighter PDRN protocols. Maintenance once or twice a year keeps skin quality steady.

Combining salmon DNA boosters with laser and other treatments

Lasers such as Pico Fraxel create controlled micro-injury to remodel texture and pores. PN or PDRN afterwards supports recovery, and many patients find their skin settles more comfortably. For pores specifically, our large pores page explains how we combine treatments.

For dryness and dull tone, PN can be paired with an HA booster for faster glow, as described on our dull and dehydrated skin page. For recovery-focused visits we may also suggest LDM skin regeneration.

Salmon DNA injections for travellers

Because the visible bumps last a day or two, book early in your trip. Flying after treatment is generally fine; keep your skin moisturised on board and avoid pressing on the treated areas. A two- to four-week stay lets you complete two sessions; otherwise one session plus a home plan is a sensible option.

For first-time visitors, our first visit guide explains what to bring and how consultations work in English.

• Skin Booster
• Rejuran
• English Speaking Skin Clinic in Myeongdong
• Glass Skin Package + Skin Booster

Cost of salmon DNA injections in Seoul

Price depends on the product (branded PN such as Rejuran or other PN/PDRN products), the amount, the areas treated, the delivery method and any combined laser. A written quote is given after consultation, naming the product and amount.

See prices and payment for how quotes and payment work. Korea's cosmetic VAT refund for foreign visitors ended on 31 December 2025; details are in our tax refund update.

Risks, side effects and safety

Every medical aesthetic treatment carries some risk. These are the effects our doctors explain before you consent:

• Small bumps at injection points for about 1–2 days.
• Redness, swelling and tenderness, usually settling within a few days.
• Bruising, especially under the eyes or with blood thinners.
• Temporary lumpiness if placed too superficially.
• Allergic reaction; people with fish or salmon allergy should not be treated.
• Infection or delayed inflammation are uncommon; report increasing pain or redness.

Aftercare checklist

1. Do not rub or massage the treated area on the day.
2. Avoid make-up for 24 hours.
3. Skip saunas, jjimjilbang, swimming and intense exercise for 48 hours.
4. Pause retinoids, acids and scrubs for 3 days.
5. Use sunscreen daily and moisturise well.
6. Avoid alcohol on the day of treatment.

Frequently asked questions

Related treatments and guides

From the Obliv Skin Journal

• Skinvive vs Rejuran Korea
• Microneedling + Skin Booster Korea
• Rejuran + Botox Combination
• Glass Skin Treatments Safe for Sensitive Skin
• Glass Skin Package + Skin Booster

Sources and further reading

1. Lee KWA et al. Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness. Int J Mol Sci, 2024
2. Torres-García et al. Efficacy and safety of polynucleotides in aesthetic medicine: systematic review and meta-analysis. Piel, 2026
3. Rho NK et al. Injectable "Skin Boosters" in Aging Skin Rejuvenation: A Current Overview. Archives of Plastic Surgery, 2024
4. American Society of Plastic Surgeons – What are injectable moisturizers, and do you need them?