Why combine Rejuran and Botox?

Lines on the face have more than one cause. Some form because the same muscles contract thousands of times a day, folding the skin into the frown, forehead and crow's feet creases. Others appear because skin itself becomes thinner, drier and less elastic, so it creases more easily and recovers more slowly. Treating only one of these causes often leaves a result that feels half-finished.

Botox addresses the first cause by temporarily relaxing the targeted muscles. Rejuran addresses the second by delivering polynucleotides, purified DNA fragments derived from salmon, into the dermis to support repair, hydration and texture. Combined, they can soften lines while making the surrounding skin look healthier and smoother.

This pairing is popular in Korean clinics precisely because it fits the Skin Architecture way of thinking: identify which layer each concern lives in, then choose the right tool for each. Muscle-driven lines need a neuromodulator; dermis-driven texture needs a booster.

What each treatment does on its own

The table compares the two treatments and what changes when you combine them. Timeframes are typical rather than guaranteed, and Botox results depend on dose, muscle strength and the brand used, such as Botox, Xeomin or a Korean toxin.

Can they be done on the same day?

In many cases, yes. Because the two products are placed at different depths and often in different areas, a doctor can plan a single visit: Rejuran across the cheeks, lower face or under-eyes, and Botox into specific muscles of the forehead, frown area or crow's feet. Combining saves time for visitors with a short stay in Seoul.

The order and technique matter. Booster injections create many small blebs and are sometimes followed by gentle pressure to settle them, while freshly injected Botox areas should not be rubbed or massaged. A careful doctor therefore keeps the treatment zones distinct, or places the booster first and the toxin last, so the Botox points are not disturbed. If you are having Rejuran I around the eyes as well as crow's feet Botox, the plan needs particular care.

Some people prefer to separate the treatments by a week or two, for example Botox first so it has settled before a booster course begins. This is equally valid and reduces the total swelling on any one day.

Who benefits most from the combination

The combination suits people with both dynamic lines and early changes in skin quality, which describes many patients in their thirties and forties. It is also useful for people who already have regular Botox and feel their skin still looks tired or dry between appointments.

It is not a substitute for lifting when sagging is the main problem. If the jawline or cheeks are descending, energy-based treatments like Ultherapy or Thermage, or a surgeon's opinion, may be more appropriate.

Treatment areas that pair well

Forehead and frown lines respond well to Botox, and the skin of the forehead often benefits from a booster if it looks dry or lined at rest. Crow's feet combine nicely with gentle under-eye boosters such as Rejuran I, which is designed for thinner skin, though the doctor must plan placement carefully near the eye.

In the lower face, Botox can be used for the masseter to slim a wide jaw, or in small amounts for a dimpled chin, while Rejuran improves texture across the cheeks. Micro-dose skin Botox for pores and oil is another option that pairs with Rejuran for an overall smoother look; see our comparison of skin Botox vs regular Botox.

• Forehead: Botox for lines plus booster for dry, crepey skin.
• Frown (glabella): Botox; skin booster only if the area looks etched at rest.
• Crow's feet: Botox plus a lighter under-eye booster such as Rejuran I.
• Cheeks and lower face: Rejuran for texture and acne marks.
• Jaw: masseter Botox alongside full-face Rejuran.

Recovery and results timeline

Most of the visible downtime comes from Rejuran: small bumps and redness for one to two days and, sometimes, a bruise. Botox points usually flatten within about an hour. Botox starts to work after three to five days and reaches full effect at about two weeks, while Rejuran's improvements in texture and glow build gradually, particularly after the second and third sessions.

Aftercare when you have both

Aftercare is largely the sum of both treatments' rules. If you want to cool swollen booster bumps, hold a clean cool compress lightly against the skin without pressing, and keep it away from fresh Botox points on the forehead and around the eyes.

• Do not rub, massage or press the Botox areas for the rest of the day.
• Stay upright for a few hours after treatment.
• Skip saunas, jjimjilbang, hot yoga and hard exercise for at least 24 hours.
• Avoid alcohol on the first evening to reduce swelling and bruising.
• Use gentle skincare and sunscreen; pause retinoids and acids for a few days.

Safety, costs and planning in Seoul

Both treatments have good safety records in experienced hands, but each has its own precautions. Botox should be avoided in pregnancy, breastfeeding and neuromuscular conditions such as myasthenia gravis, and can occasionally cause a temporary heavy brow or eyelid if it spreads to nearby muscles. Rejuran can cause bumps, bruising and, rarely, nodules or allergic reactions; tell your doctor about any fish allergy.

Costs depend on the Botox brand and units, the number of Rejuran syringes and whether you choose a course. We provide a personal written quote rather than fixed prices; see prices and payment. For visitors, book the combined session early in your trip so bumps settle before photos and the doctor can review you if needed. Our Skinvive vs Rejuran guide explains when an HA booster might suit you better.

Frequently asked questions

Related treatments and guides

Keep reading

• Skinvive vs Rejuran Korea
• Skin Botox vs Regular Botox in Seoul
• Natural Botox Results for Foreign Patients
• Pico Laser + Rejuran in Myeongdong
• Botox + Lifting Laser Same Day

Sources

1. Cleveland Clinic – Botox (Botulinum Toxin): What It Is, Results & Side Effects
2. DermNet – Botulinum toxin
3. Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness (PMC)